Equipment for in vivo voltammetry
All what one may need to set-up in vivo voltammetry laboratory, including headstages for fast cyclic voltammetry and amperometry, potentiostat, brain stimulator with stabilized current isolation unit, software designed for FSCV and amperometry and controlling stimulation, working, reference and stimulating electrodes.
From establishing of a working in vivo voltammetry laboratory and training of staff to refinement and application of the methods in preclinical pharmacology.
We arrange videoconferencing, which will take you through the entire procedure from the first calibration all the way to registration of dopamine even at nanomolar levels.
Brain stimulation and monitoring behaviour
The same animals undergoing in vivo voltammetry can be tested in some behavioral protocols without the need to register the dopamine transient but with optical or electrical stimulation of specific brain areas. We have developed several approaches that permit to perform wireless brain stimulation and to build sophisticated behavioral tests without significant investment in the new equipment.
We perform real-time neurochemical analysis of dopamine, noradrenaline, serotonin release and re-uptake in the smallest brain structures, and testing the effects of drugs and new compounds on the overflow of monoamines in different brain areas of intact mouse and rat brain.
Optional two-channel head stage is a part of the Invilog In Vivo Voltammetry Setup This head stage lets you to record dynamics of neurotransmitter release and re-uptake in two distinct brain regions simultaneously. For example you may stimulate medial forebrain bundle and obtain in the same experiment curves of dopamine overflow in the dorsal and ventral striatum.
FCV Analyzer now includes current stabilized stimulus isolation unit (SIU). This unit is working together with inbuilt in the FCV Analyzer stimulator. Thanks to replaceable batteries the SIU provides the lowest noise mono- or bipolar (biphasic) stimulation up to ±1 mA. You don’t need anymore other specific equipment than FCV Analyzer with inbuilt SIU to set up in vivo voltammetry in your lab.
Invilog bubble level can now be used with any stereotaxic frame even those without threaded hole on the side of the frame. What one needs is simply to glue a tiny metal plate (see it on the insert) with help of two sided scotch.